Synthesis of novel menthol derivatives containing 1,2,3-triazole group and their in vitro antibacterial activities
نویسندگان
چکیده
New N-substituted ?-aminonitrile derivatives from menthol were synthesized by consecutive succinic ester formation, propargylation, 1,3-dipolar Huisgen cycloaddition and Strecker reaction. The structures of the compounds confirmed diverse spectroscopic techniques including 1HNMR, 13C-NMR, ESI-MS IR. novel evaluated for their in vitro antibacterial activities against Staphylococcus aureus as Gram-positive Escherichia coli Gram-negative bacteria. These demonstrated a strong inhibitory effect S. with minimum concentration (MIC) values ranged 32?128 ?g mL-1. Derivatives 6a2, 6b1, 6b4 6b5 MIC value 32 mL-1 exhibited best effects.
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ژورنال
عنوان ژورنال: Journal of The Serbian Chemical Society
سال: 2023
ISSN: ['1820-7421', '0352-5139']
DOI: https://doi.org/10.2298/jsc220813006k